3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester
- CAS：211915-84-3
- purity：99%
Details
Reliable Quality 3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester 211915-84-3 Hot Sale with Chinese Manufacturer
- Molecular Formula: C27H26N6O3
- Molecular Weight: 482.542
- Boiling Point: 756.382 °C at 760 mmHg
- PKA: 4.21±0.10(Predicted)
- Flash Point: 411.245 °C
- PSA： 113.14000
- Density: 1.255 g/cm3
- LogP: 4.12508
211915-84-3 Relevant articles
Preparation method of anticoagulant drug dabigatran etexilate and analogues thereof
-
Paragraph 0039; 0041-0043, (2020/05/01)
The invention discloses a preparation me...
Method for purifying dabigatran etexilate intermediate
-
Paragraph 0022-0026, (2020/03/23)
The invention relates to a purification ...
Preparation method of dabigatran intermediate
-
Paragraph 0036; 0037, (2019/12/25)
The invention discloses a dabigatran int...
Dabigatran etexilate key intermediate preparation method
-
, (2019/10/01)
The invention relates to the field of ph...
211915-84-3 Process route
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-
isopropyl 2?(4?cyanophenylamino)acetate
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amino}propanoate](/upload/2026/10/f2157c71d7e447139103450ad10cde3a_50282545-1579-40f7-b0cc-f67ae4e603bb.png)
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212322-56-0
ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate
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![3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester](/upload/2026/10/ee29531748be4c748d09d75d5c9883a5_a32f6753-6d21-4abc-a70f-46d42abc4f12.png)
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211915-84-3
3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
| Conditions | Yield |
|---|---|
|
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 10 - 35 ℃;
|
82%
|
-
-
42288-26-6
(4-cyanophenyl)glycine
-
-
212322-56-0
ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate
-
-
211915-84-3
3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
| Conditions | Yield |
|---|---|
|
(4-cyanophenyl)glycine; ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate;
With
1,1'-carbonyldiimidazole;
In
Isopropyl acetate;
at 20 ℃;
for 4h;
With
acetic acid;
In
Isopropyl acetate;
for 2h;
Reflux;
|
95%
|
|
(4-cyanophenyl)glycine;
With
1,1'-carbonyldiimidazole;
In
toluene;
at 50 ℃;
ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate;
In
toluene;
at 20 - 25 ℃;
Temperature;
|
93.97%
|
|
(4-cyanophenyl)glycine;
With
benzotriazol-1-ol; dicyclohexyl-carbodiimide;
In
N,N-dimethyl-formamide;
at 3 ℃;
for 1h;
ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 6h;
Temperature;
Further stages;
|
91.1%
|
|
(4-cyanophenyl)glycine;
With
1,1'-carbonyldiimidazole;
In
diethyl ether; dichloromethane;
at 40 ℃;
Inert atmosphere;
Reflux;
ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate;
In
diethyl ether; dichloromethane;
at 40 ℃;
With
acetic acid;
In
diethyl ether; dichloromethane;
at 50 - 60 ℃;
Solvent;
|
86%
|
|
(4-cyanophenyl)glycine;
With
pivaloyl chloride; triethylamine;
In
tetrahydrofuran;
at 0 - 10 ℃;
for 0.5h;
ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate;
In
tetrahydrofuran;
at 45 ℃;
for 2h;
Reagent/catalyst;
Temperature;
|
85%
|
|
(4-cyanophenyl)glycine;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 0.75h;
ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate;
In
N,N-dimethyl-formamide;
at 20 ℃;
|
83%
|
|
|
61%
|
|
(4-cyanophenyl)glycine;
With
1,1'-Carbonyl-di-(1,2,4-triazole);
In
tetrahydrofuran;
at 35 ℃;
for 1 - 2h;
Industry scale;
ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate;
In
tetrahydrofuran;
at 47 - 53 ℃;
for 6 - 7h;
Industry scale;
With
acetic acid;
In
acetic acid butyl ester;
at 85 - 90 ℃;
for 2.5h;
Industry scale;
|
|
|
(4-cyanophenyl)glycine;
With
1,1'-carbonyldiimidazole;
In
tetrahydrofuran;
for 0.75h;
Inert atmosphere;
Reflux;
ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate;
In
tetrahydrofuran;
for 6h;
Reflux;
With
acetic acid;
for 1h;
Reflux;
|
|
|
(4-cyanophenyl)glycine;
With
1,1'-carbonyldiimidazole;
In
tetrahydrofuran;
at 50 - 55 ℃;
for 2h;
ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate;
In
tetrahydrofuran;
at 50 - 65 ℃;
for 50h;
Product distribution / selectivity;
|
|
|
(4-cyanophenyl)glycine;
With
1,1'-carbonyldiimidazole;
In
tetrahydrofuran;
for 0.666667h;
Inert atmosphere;
Reflux;
ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate;
In
tetrahydrofuran;
for 7h;
Inert atmosphere;
Reflux;
With
acetic acid;
for 3h;
Reflux;
|
|
|
(4-cyanophenyl)glycine;
With
1,1'-carbonyldiimidazole;
In
toluene;
at 55 - 60 ℃;
for 2h;
ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate;
In
toluene;
at 60 - 100 ℃;
for 6h;
|
|
|
(4-cyanophenyl)glycine; ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate;
With
1,1'-carbonyldiimidazole;
In
tetrahydrofuran;
at 25 ℃;
for 24h;
With
acetic acid;
In
ethyl acetate;
at 70 ℃;
for 12h;
|
|
|
(4-cyanophenyl)glycine;
With
1,1'-carbonyldiimidazole;
In
tetrahydrofuran;
at 50 - 55 ℃;
for 3h;
ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate;
In
tetrahydrofuran;
at 50 - 65 ℃;
for 52h;
With
acetic acid;
at 95 - 100 ℃;
for 5h;
|
300 g
|
|
(4-cyanophenyl)glycine;
With
Imidazole hydrochloride; 1,1'-carbonyldiimidazole;
In
dichloromethane;
at 45 - 50 ℃;
for 1h;
Inert atmosphere;
ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate;
In
dichloromethane;
at 45 - 50 ℃;
for 1h;
Inert atmosphere;
With
acetic acid;
In
ethyl acetate;
for 6h;
Temperature;
Solvent;
Time;
Inert atmosphere;
Reflux;
|
127 g
|
|
(4-cyanophenyl)glycine;
With
1,1'-carbonyldiimidazole;
In
toluene;
at 25 - 60 ℃;
ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate;
In
toluene;
at 60 - 100 ℃;
for 6h;
|
|
|
(4-cyanophenyl)glycine;
With
1,1'-carbonyldiimidazole;
In
N,N-dimethyl-formamide;
at 10 - 50 ℃;
for 3h;
Large scale;
ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate;
In
N,N-dimethyl-formamide;
for 12h;
Large scale;
With
acetic acid;
at 110 ℃;
for 5h;
Solvent;
Temperature;
Large scale;
|
211915-84-3 Upstream products
-
948551-71-1
3-({3-[2-(4-cyano-phenylamino)-acetylamino]-4-methylamino-benzoyl}-pyridin-2-yl-amino)-ethyl propanoate
-
82357-48-0
4-methylamino-3-nitro-benzoic acid chloride
-
41263-74-5
4-(methylamino)-3-nitrobenzoic acid
-
212322-56-0
ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate
211915-84-3 Downstream products
-
211915-06-9
dabigatran etexilate
-
429658-95-7
3-({2-[(4-carbamimidoylphenylamino)methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}pyridin-2-yl-amino)propionic acid ethyl ester
-
1381757-44-3
2-(N-(3-ethoxy-3-oxopropyl)-2-((4-(N'-(hexyloxycarbonyl)carbamimidoyl)phenylamino)methyl)-1-methyl-1H-benzo[d]imidazole-5-carboxamido)pyridine-1-oxide
-
658078-29-6
C27 H29 N7 O4
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